Solal CholTrol™ (Cholesterol and cardiovascular support)

R 213.86
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CholTrolTM contains artichoke extract and beta-sitosterol that work to support and maintain healthy cholesterol levels.           

Product Composition 

Each capsule contains the following active ingredients:

Artichoke extract (standardised to contains 30% Luteolin)       

100 mg

Beta-Sitosterol

370 mg

 

Inactive ingredients: Magnesium stearate.

 Storage Instructions

 Store in a cool dry place below 25°C. Keep out of reach of children.

Pharmacological Action

Luteolin is reported to be an active component of artichoke that reduces hepatic cholesterol synthesis by indirect inhibition of the HMGCoA-reductase enzyme in animal studies.  Human studies show a modest reduction in total cholesterol of approximately 18% after 6 weeks of use. Beta-sitosterol has multiple mechanisms of action: It lowers cholesterol levels by interfering with the intestinal absorption of cholesterol and increasing bile acid secretion. Another mechanism for this effect demonstrated during in vitro studies, is the inhibition of sterol-reductase, an essential enzyme in the process of cholesterol biosynthesis. Beta-sitosterol may interfere with the uptake of micellar cholesterol leading to decreased plasma membrane cholesterol influx and cholesteryl ester secretion. Data indicates that dietary plant sterols disrupt cholesterol homeostasis by affecting two critical regulatory pathways of lipid metabolism. It has been suggested that plant sterols limit cholesterol ester availability in cells leading to increased degradation of apoB100 (in HepG2 liver cells) and apoB48 (in Caco2 intestinal cells). This would result in the decreased production of VLDL from the liver and chylomicrons from the intestine, precursors of LDL-C and chylomicron remnants, respectively. Beta-sitosterol significantly reduces total and low-density lipoprotein (LDL) cholesterol levels, but has little or no effect on high-density lipoprotein (HDL) cholesterol levels.

Dosage Directions

Adults: e 1 capsule twice daily with meals. 

Product Warnings

Do not use this product if you are hypersensitive (allergic) to any of the ingredients. If you are on any medication or suffering from any medical condition, it is advisable to seek medical advice before starting any new medicine, supplement or remedy. Do not exceed recommended dosages unless on the advice of a healthcare practitioner.

Patients with asthma and kidney disorders must not use CholTrolTM without consulting a doctor. Individuals with a history of gallstones should consult their healthcare practitioner prior to use. This unregistered medicine has not been evaluated by the SAHPRA for its quality, safety or intended use.

Side Effects

Side effects may include gastrointestinal reactions including slight diarrhoea, abdominal spasm and epigastric complaints like nausea, and heartburn.

Contraindications

Hypersensitivity to the active substance or to plants of the Asteraceae family (Compositae) e.g. daisies and ragweed.

Individuals suffering from bile duct obstruction, cholangitis, gallstones and any other biliary diseases should not use this product.

Patients with hepatitis or sitosterolemia should not use this product.

Interactions

There are no known interactions.

Pregnancy and Breastfeeding

Safety during pregnancy and whilst breastfeeding has not been established.

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